TABLE 2.

GeneChip Evaluation of Gene Expression in the Male Rhesus Macaque Arcuate Nucleus

			AM			PM
Gene Symbol	Description	ID	Old (Control)	Young	Old HS	Old	P value
Steroid receptors
AR	Androgen receptor	13806207	5.81 ± 0.10	5.89 ± 0.05	5.81 ± 0.08	6.42 ± 0.08*	0.0001
ESR1	Estrogen receptor 1	13827480	5.54 ± 0.09	5.92 ± 0.10	5.65 ± 0.06	5.86 ± 0.28	0.2026
ESR2	Estrogen receptor 2	13784393	4.64 ± 0.13	4.56 ± 0.06	4.74 ± 0.11	4.50 ± 0.06	0.3874
PGR	Progesterone receptor	13658473	6.89 ± 0.09	7.17 ± 0.08	6.75 ± 0.05	6.46 ± 0.25	0.0090
Neuropeptides and receptors
GNRH1	Gonadotropin-releasing hormone 1	13790870	6.94 ± 0.15	7.03 ± 0.16	7.10 ± 0.28	7.58 ± 0.35	0.2997
GNRH2	Gonadotropin-releasing hormone 2	13606683	5.46 ± 0.11	5.38 ± 0.15	5.57 ± 0.09	5.10 ± 0.16	0.1015
GNRHR	Gonadotropin-releasing hormone receptor	13752156	4.31 ± 0.40	4.27 ± 0.43	3.81 ± 0.41	5.28 ± 0.75	0.2657
KISS1	Kisspeptin	13589384	5.28 ± 0.07	5.14 ± 0.15	5.18 ± 0.11	5.06 ± 0.19	0.6768
KISS1R	Kisspeptin receptor	13820906	6.18 ± 0.13	6.14 ± 0.09	6.01 ± 0.14	5.93 ± 0.11	0.4600
OPRK1	Opioid receptor, kappa 1	13791718	6.56 ± 0.11	6.50 ± 0.12	6.82 ± 0.09	6.74 ± 0.09	0.1592
PDYN	Prodynorphin	13612278	6.38 ± 0.10	6.50 ± 0.13	6.35 ± 0.18	6.74 ± 0.19	0.3140
TAC1	Tachykinin 1	13735408	7.63 ± 0.19	7.54 ± 0.20	7.65 ± 0.09	7.64 ± 0.34	0.9802
TACR1	Tachykinin receptor 1	13644855	4.49 ± 0.20	4.62 ± 0.12	4.67 ± 0.23	4.74 ± 0.18	0.8168
TAC3	Tachykinin 3	13625903	6.40 ± 0.28	6.53 ± 0.21	5.89 ± 0.15	6.01 ± 0.47	0.3154
TACR3	Tachykinin receptor 3	13757467	4.48 ± 0.10	4.41 ± 0.16	4.17 ± 0.08	4.38 ± 0.32	0.5849

Affymetrix GeneChip Rhesus 1.0 ST Arrays were used to profile gene expression in the arcuate nucleus. Values represent means ± SEMs of bi-weighted average signal intensity. AM = morning necropsy; PM = evening necropsy; HS = 6 months of T and DHEA hormone supplementation.

^*P<0.05, ANOVA with post hoc Bonferroni adjustment, relative to the Old (Control) group.