Ventral striatum-insula connectivity. Connectivity between the ventral striatum and mid/posterior insula (a.) demonstrated a significant quadratic relationship, with connectivity being negative during adolescence, but not in childhood or adulthood. Quadratic effects in connectivity between ventral striatum and ventral anterior insula (b.), and between ventral striatum and dorsal anterior insula became trends and non-significant, respectively, after Sequential Bonferroni Correction. (c.). * denotes significant differences from zero (p<.05). † denotes trend level differences from zero (p<.10). †† denotes not significant after Sequential Bonferroni Correction (p<.10). All ROIs depicted at in x = 35.