Fig. 7.

Comparison of adhesion phenotypes between simulation scenarios. a The plot shows the mean adhesive state of disseminated cells ${ā}^D$ [Eq. (4)] in equilibrium (k=1000) as a function of the adhesion heterogeneity parameter γ for α=1). ${ā}^D$ decreases significantly with higher γ-values for all four scenarios (p<0.001). For fixed γ-values, ${ā}^D$ is always significantly higher for scenarios III and IV (α=0, CONTROL ⁻) than for scenarios I and II (α=1, CONTROL ⁺, p<0.01). See Additional files 6 and 7 for full statistics. b The plot shows the difference between mean adhesion phenotypes in the distance measure d_a [Eq. (5)] as a function of the adhesion heterogeneity parameter γ. Significance levels are similar to (a). See Additional files 8 and 9 for full statistics. Colours of data points are in accordance with scenario colours in Fig. 3