Table 3.
Mean HbF Levels Among Haplotypes
| aCSSCD | |||||||||
| RFLP classification | SNP-based classification | Failed RFLP classification | |||||||
| Haplotype | n | mean | sd | n | mean | sd | n | mean | sd |
| BEN/BEN | 253 | 6.69 | 5.58 | 379 | 6.39 | 5.14 | 89 | 6.07 | 4.32 |
| BEN/CAR | 157 | 7.32 | 7.63 | 261 | 7.04 | 6.77 | 74 | 6.83 | 5.37 |
| BEN/SEN | 62 | 8.18 | 4.75 | 116 | 7.99 | 5.32 | 33 | 7.72 | 5.50 |
| BEN/CAM | 32 | 4.81 | 3.89 | 53 | 5.33 | 5.19 | 15 | 6.06 | 6.18 |
| CAR/CAR | 21 | 5.52 | 3.71 | 41 | 5.59 | 3.90 | 16 | 5.66 | 4.47 |
| CAR/SEN | 11 | 9.80 | 3.48 | 24 | 8.91 | 7.59 | 7 | 11.24 | 13.14 |
| CAR/CAM | 9 | 3.80 | 2.51 | 18 | 3.96 | 3.24 | 8 | 4.41 | 4.16 |
| SEN/SEN | 7 | 9.24 | 5.30 | 13 | 8.74 | 4.35 | 5 | 7.58 | 3.35 |
| CAM/SEN | 3 | 7.43 | 6.23 | 9 | 8.61 | 6.02 | 5 | 9.24 | 7.17 |
| BEN/AI | 2 | 4.20 | 5.37 | - | - | - | - | - | - |
| CAM/CAM | 1 | 7.00 | - | 1 | 7.00 | - | - | - | - |
| CAR/AI | 1 | 16.10 | - | 1 | 16.10 | - | - | - | - |
| bSW Saudi | |||||||||
| RFLP classification | SNP-based classification | Failed RFLP classification | |||||||
| Haplotype | n | mean | sd | n | mean | sd | n | mean | sd |
| BEN/BEN | 39 | 11.22 | 5.32 | 48 | 10.28 | 4.19 | - | - | - |
| CAR/CAR | 11 | 9.35 | 5.07 | - | - | - | - | - | - |
| BEN/SEN | 2 | 8.65 | 0.64 | - | - | - | - | - | - |
| BEN/CAR | 1 | 6.50 | - | 1 | 3.10 | - | - | - | - |
| SEN/SEN | 1 | 20.40 | - | - | - | - | - | - | - |
| UNK | 1 | 12.60 | - | - | - | - | - | - | - |
| AI/AI | - | - | - | 1 | 20.40 | - | - | - | - |
| BEN/CAM | - | - | - | 2 | 10.15 | 9.69 | - | - | - |
| BEN/UNK | - | - | - | 3 | 20.20 | 8.64 | - | - | - |
| cE Saudi | |||||||||
| RFLP classification | SNP-based classification | Failed RFLP classification | |||||||
| Haplotype | n | mean | sd | n | mean | sd | n | mean | sd |
| AI/AI | 30 | 18.03 | 5.39 | 30 | 18.03 | 5.39 | - | - | - |
Included are 559 patients with HbF phenotypes classified with RFLP method, 916 patients with HbF phenotypes classified with SNP-based method, and 252 samples that failed RFLP classification but were classifiable with SNP-based method. (n) is the number of patients in the corresponding haplotype class, (mean) is the mean of HbF per haplotype, (sd) is the standard deviation. aCSSCD are African Americans; bSW Saudi is Saudi patients from Southwestern Province; cE Saudi are Saudi patients from the Eastern Province. UNK-unknown