Fig. 4.

Effects of diet and exercise on the expression of genes associated with rRNA processing and ribosome export. The effects of the intervention on Nop56 mRNA levels (a) and Ncl mRNA levels (b) (both genes being involved in rRNA processing and ribosome assembly), Npm1 mRNA levels (c) and Fbl mRNA levels (d) (genes involved with nuclear ribosome export), and 28S rRNA transcript levels (e) and 18S rRNA transcript levels (f) (both markers being indicative of downstream rRNA processing from the pre-45S transcript). All data are presented as mean ± SD (n = 10–16 rats per group), group mean values are presented within each bar, 95% confidence intervals are presented in parentheses within each bar, and bars with different superscript letters indicate between-treatment differences (p < 0.05). O-CON OLETF rats consuming a control diet during weeks 20–32 and were not treadmill-trained, O-WD/SED OLETF rats consuming a Western diet during weeks 20–32 and were not treadmill-trained, O-WD/EX OLETF rats consuming a Western diet during weeks 20–32 and were treadmill-trained 5 days/week