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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Stroke. 2017 May 19;48(7):1818–1826. doi: 10.1161/STROKEAHA.117.016726

Table 2.

Risk factors for shorter survival among participants with incident ischemic stroke

Unadjusted* Fully Adjusted

n HR 95% CI p-value Int. § n HR 95% CI p-value Int. §
Pre-Frail
 <80 years 300 1.48 1.13, 1.94 0.003 0.20 294 1.64 1.23, 2.18 0.001 0.04
 ≥80 years 232 1.11 0.78, 1.57 0.57 221 0.99 0.68, 1.46 0.96
Frail
 <80 years 300 2.08 1.38, 3.13 <0.001 0.05 294 2.03 1.31, 3.16 0.002 0.06
 ≥80 years 232 1.18 0.79, 1.76 0.43 221 1.13 0.71, 1.80 0.61
CRP || 616 1.05 0.99, 1.10 0.11 606 1.05 0.99, 1.12 0.08
IL-6 ||
 <80 years 294 1.47 1.30, 1.67 <0.001 0.007 292 1.41 1.23, 1.62 <0.001 0.03
 ≥80 years 291 1.13 0.97, 1.30 0.12 285 1.12 0.95, 1.31 0.17
Cystatin C || 578 2.24 1.81, 2.77 <0.001 568 1.97 1.55, 2.50 <0.001
Systolic Blood Pressure# 637 1.01 0.97, 1.04 0.62 622 1.02 0.98, 1.05 0.39
Diastolic Blood Pressure# 637 0.96 0.90, 1.03 0.23 622 0.99 0.92, 1.06 0.79
Total Cholesterol
 <80 years 312 0.99 0.96, 1.03 0.70 0.02 309 1.02 0.98, 1.05 0.36 0.10
 ≥80 years 307 0.94 0.92, 0.97 <0.001 300 0.98 0.95, 1.00 0.16
*

Adjusted for time between risk factor assessment and stroke

Adjusted for time between risk factor assessment and stroke, ischemic stroke subtype, stroke location, race, sex, education attainment, smoking status, alcohol consumption, living alone status, atrial fibrillation, coronary heart disease, congestive heart failure, diabetes, depression (CES-D>12), low cognitive function (3MSE<80), BMI, anti-coagulant use, and anti-hypertensive medication use

n in each analysis

§

p-value for interactions

||

per doubling in concentration

#

per 10 mm Hg

per 10 mg/dL

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