(A) Generation of optic cups from skin biopsy. Scale bars, iPSCs (left) 250μm, iPSC-derived optic cup (right) 200 μm. (B) Representative images of ciliary structures in iPSC-derived optic cups: cilia (I); ciliary vesicle, CV (II); docked MC (III-V); intracellular cilia (VI). Scale bar, 500 nm. (C) Classification of MC and ciliary structures in iPSC-derived optic cups at day 200 analyzed by transmission electron microscopy (TEM); Ctrl-1 (total=19), LCA-2A (total=23), LCA-2F (total=14), from LCA-1 (total=14).