Table 1. Demographic and baseline ECG characteristics of patients who received sotalol.

	Discovery cohort	Replication cohort	Pvalue
Subjects who received sotalol	495	495	ns
Age (years)	29±10.8	28±10.2	ns
Female (%)	311(63%)	303(61%)	ns
Kalemia (mmol/l)	4±0.3	4.1±0.3	<0.001
Plasma sotalol at H3 (ng/ml)	398±134	448±153	<0.001
European / North-African	448 (90%)/47(10%)	431(87%) / 64(13%)	ns
Baseline QTcF (mean±SD), msec	389±17	387±17	0.02
Baseline QTcF (median,[IQR]), msec	388 [374; 398]	389 [377; 399]	0.03
Baseline QTcF (Min; Max), msec	333; 432	333; 439
Baseline RR (mean±SD), msec	905±115	907±102	ns
Baseline TAmp (mean±SD), mV	512±177	531±183	ns
Baseline TpTe (mean±SD), msec	70±9	67±9	<0.001
Baseline Notching (%)	0(0%)	0(0%)	ns

ns represents p>0.05. Mean ± standard deviation and median [interquartile range] are shown.