Table 4. Electrocardiographic findings of patients who presented or did not present with notching 3 hours post sotalol administration in the discovery and replication cohort.

	Discovery cohort		Replication cohort		Pvalue
	Notching	No Notch	Notching	No Notch
Number of subjects	40	445	51	436
Female (%)	40(100%)	263(59%)	50(98%)	247(57%)	<0.0001
ΔQTcF (%)	7.7±4†	5.1±3.3‡	9±3.7†	5.2±3.4‡	<0.0001
ΔTAmp (%)	36.7±11.9†	11.3±14.2‡	32.1±17.5†	10.4±13.4‡	<0.0001
ΔTpTe (%)	53.6±30†	10.4±11.8‡	51±38.4†	11.7±12.1‡	<0.0001
Principal Component 1	-2.5±1.5†	0.3±1.1‡	-2.3±1.8†	0.3±1.1‡	<0.0001
Principal Component 2	0.7±1.1 †	-0.1±0.7 ‡	0.3±1 †	0±0.7 ‡	<0.0001
Principal Component 3	0.5±1.2 †	0±0.5 ‡	0.3±1.3 †	0±0.5 ‡	<0.0001

Pvalue: One-way Anova with Tukey’s post-test used.

^†: Significant vs. No notch groups (discovery and validation cohort);

^‡: Significant vs. notching groups (discovery and validation cohort).