Table 3.
Primary tumor characteristics of the cohorts according to genotype
| BRAF n = 87 (100.0) | NRAS n = 53 (100.0) | Wild type n = 72 (100.0) | Total n = 212a (100.0) | p-value | |
|---|---|---|---|---|---|
| Localization | |||||
| Acral | 3 (3.5) | 4 (8.0) | 14 (19.4) | 21 (10.1) | 0.002* |
| Head / neck | 14 (16.5) | 5 (10.0) | 15 (20.8) | 34 (16.4) | |
| Arms | 7 (8.2) | 10 (20.0) | 10 (13.9) | 27 (13.0) | |
| Trunk | 39 (45.9) | 19 (38.0) | 15 (20.8) | 73 (35.3) | |
| Legs | 22 (25.9) | 10 (20.0) | 14 (19.4) | 46 (22.2) | |
| Mucosal | 0 (0.0) | 2 (4.0) | 4 (5.6) | 6 (2.9) | |
| Histologic subtypea | |||||
| ALM | 3 (3.53) | 2 (4.0) | 11 (15.3) | 16 (7.7) | 0.021 |
| LMM | 2 (2.35) | 0 (0.0) | 2 (2.78) | 4 (1.93) | |
| NM | 32 (37.7) | 26 (52.0) | 27 (37.5) | 85 (41.1) | |
| SSM | 37 (43.5) | 14 (28.0) | 17 (23.6) | 68 (32.9) | |
| unclassified | 11 (12.9) | 8 (16.0) | 15 (20.8) | 34 (16.4) | |
| Breslow’s indexb | |||||
| ≤ 1.00 mm | 43 (50.6) | 26 (52.0) | 32 (45.1) | 101 (49.0) | 0.241 |
| 1.01 – 2.00 mm | 21 (24.7) | 9 (18.0) | 14 (19.7) | 44 (21.3) | |
| 2.01 – 4.00 mm | 17 (20.0) | 8 (16.0) | 12 (16.9) | 37 (18.0) | |
| ≥ 4.01 mm | 4 (4.7) | 7 (14.0) | 13 (18.3) | 24 (11.7) | |
| Clark levelc | |||||
| II | 3 (3.8) | 1 (2.3) | 4 (6.6) | 8 (4.4) | 0.094 |
| III | 25 (31.3) | 9 (20.9) | 9 (14.8) | 43 (23.4) | |
| IV | 45 (56.3) | 30 (69.8) | 36 (59.0) | 111 (60.3) | |
| V | 7 (8.8) | 3 (7.0) | 12 (19.7) | 22 (12.0) | |
| Ulzerationd | |||||
| no | 49 (60.5) | 23 (47.9) | 36 (50.7) | 108 (54.0) | 0.301 |
| yes | 32 (39.5) | 25 (52.1) | 35 (49.3) | 92 (46.0) | |
| Mitotic activitye | |||||
| no | 15 (37.5) | 4 (16.0) | 3 (7.0) | 22 (20.4) | 0.002* |
| yes | 25 (62.5) | 21 (84.0) | 40 (93.0) | 86 (79.6) | |
Pathologic features of the primary tumors are indicated according to genotype. The categorical variables were compared with the Chi-square test; the significance level was adjusted with the Bonferroni correction with p < 0.008 considered significant (*). Mitotic activity was defined as presence of ≥ 1 mitosis per high power field. aNo data on the histologic subtype for n = 5; bno data on Breslow’s index for n = 6; cno data on Clark level available for n = 28; dulceration unknown for n = 12; emissing data for mitotic activity in primary tumors for n = 104; ALM acral lentiginous melanoma, LMM lentigo maligna melanoma, NM nodular melanoma, SSM superficial spreading melanoma