Table 4.
Patterns of disease progressiona
| BRAF n = 87 (100.0) | NRAS n = 53 (100.0) | Wild type n = 72 (100.0) | total n = 212a (100.0) | p-value | |
|---|---|---|---|---|---|
| Local relapse | |||||
| no | 86 (98.9) | 49 (92.5) | 71 (98.6) | 206 (97.2) | 0.057 |
| yes | 1 (1.2) | 4 (7.6) | 1 (1.4) | 6 (2.8) | |
| Relapse of nodal disease (loco-regional) | |||||
| no | 56 (64.4) | 21 (39.6) | 43 (59.7) | 120 (56.6) | 0.013* |
| yes | 31 (35.6) | 32 (60.4) | 29 (40.3) | 92 (43.4) | |
| Distant metastasesb | |||||
| no | 18 (21.2) | 6 (12.0) | 23 (33.3) | 47 (23.0) | 0.021 |
| yes | 67 (78.8) | 44 (88.0) | 46 (66.7) | 157 (77.0) | |
The frequency and types of disease progression are displayed according to the genotype. Patients were allowed to have more than one progression type. Statistical analyses were performed with the Chi-square test; the significance level was adjusted with the Bonferroni correction with p < 0.017 considered significant (*). a n = 4 patients had disease progression, but the specific progression type was unknown; bpatients initially presenting in stage M1 (IV) were excluded (n = 8)