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. 2017 Aug 11;12(8):e0182448. doi: 10.1371/journal.pone.0182448

Fig 5. Regional plots showing results of the meta-analyses of IR-C.

Fig 5

(A) Meta-analysis results with the top SNP in TOMM40 (rs157582) shown; (B) results when estimating the association with the TOMM40 SNP shown (rs157582), conditioning on the top APOE SNP (rs769449); and (C) results when estimating the association with the APOE SNP (rs769449), conditioning on the top TOMM40 SNP (rs157582). The y-axis shows -log10 P-values; x-axis shows position of genes on chromosome 19 with SNPs 400-kb in both directions of the SNP of interest. The diamond represents the top SNP of interest. The circles represent each genotyped SNP in this region; the circle color indicates pairwise linkage disequilibrium (LD) in relation to the top SNP (calculated from hg19/1000 Genomes Nov 2014 EUR). The solid (blue) line indicates the recombination rate.