Light micrographs of trichrome-stained, transversely sectioned
cryoinjured hearts on days 5, 15, and 60 with the C57BL/6
(Left) and the MRL (Right) mice.
(A) C57BL/6, 5 days postinjury, 40×.
(B) MRL, 5 days postinjury, 40×. (C)
C57BL/6, 15 days postinjury, 4× (Inset, 40×).
(D) MRL, 15 days postinjury, 4× (Inset,
40×). (E) C57BL/6, 60 days postinjury, 4×.
(F) MRL, 60 days post injury, 4×. The extent of injury
in MRL and C57BL/6 hearts is indicated by arrows in C
and D. By day 60, the C57BL/6 wound is entirely scar
tissue. Conversely, the injured MRL myocardium seems normal with only a
small amount of scar tissue on the epicardial surface. The right
ventricular site of injury is indicated as RV in E and
F.