Fig. 5.

Early-phase toxic effects after Bz treatment. Mice aged 10 or 14 weeks were injected with vehicle or Bz twice on day 1 and day 4 (10wk, 14wk, 10wkBz, and 14wkBz, respectively). One day after the second Bz injection, mice were sacrificed and blood specimens were analyzed. a Blood cell counts. b Renal and liver function tests: Serum Cr, AST, and ALT. c Serum IFN-γ, IL-6, and TNF-α levels. Values expressed as median with quartile range. Statistical analysis performed using one-way ANOVA analyses with Turkey post-hoc test. ALT alanine aminotransferase, AST aspartate aminotransferase, Cr creatinine, Hb hemoglobin, IFN-γ interferon-gamma, IL-6 interleukin-6, Plt platelet, TNF-α tumor necrosis alpha, WBC white blood cell