Table 1. miR-122 sites are conserved across all HCV isolates.
| Genotype | Subtype | Accession | 5′ noncoding region |
|---|---|---|---|
| 1 | a | AF009606 (H77) | -GCCAGCCCCCUGAUGGGG-GCGACACUCCACCAUGAAUCACUCCCCUGUG |
| b | M58335 | -----------C.......-...............AG.............. | |
| c | D14853 | -..................-.......... G.................... | |
| 2 | a | D00944 | -A..C.....UAAUA....--......... G.................... |
| b | D10988 | -...C..............-..........G.................... | |
| c | D50409 | -A..C.....UAA.A....--.........G.................... | |
| k | AB031663 | U...C.....UAA...... --.........G.................... | |
| 3 | a | D17763 | -A..U...U.U.ACGA..C---..............G.............. |
| b | D49374 | -...U...U.U.UCGA..C---............................. | |
| k | D63821 | -...U...U.U.UCGA..C---............................. | |
| 4 | a | DQ295833* | --------------.....-...............AG.............. |
| 5 | a | D50466* | -A..C.....U.AU.....--...............-.............. |
| 6 | a | D88476* | -.........U.A.C....--.........G....U-.............. |
| b | D84262 | -.........U.A.C....--...............-.............. | |
| d | D84264 | -.........UAAU-....--...............-.............. | |
| f | D63822 | -.........U.AC-....--...............-.............. | |
| h | D84265 | -.........UAAU-....--...............-.............. | |
| k | D84264 | -.........UAAU-....--...............-.............. |
5′ NCRs (nts 1-49) of HCV isolates belonging to each of the confirmed genotypes/subtypes in the euHCVdb: http://euhcvdb.incp.fr/euHCVdb/jsp/nomen_tabl.jsp (Combet C, Garnier N, Charavay C, Grando D, Crisan D, Lopez J, Dehne-Garcia A, Geourjon C, Bettler E, Hulo C, Mercier PL, Bartenschlager R, Diepolder H, Moradpour D, Pawlotsky JM, Rice CM, Trepo C, Penin F and Deléage G. Nucleic Acids Res, 2007, 35:D363-66). Confirmed sequences for genotype 4a, 5a and 6a are truncated at the 5′ end; hence, provisionally assigned sequences were retrieved for analysis.