Table 1.

Immune response in scabies

	Ordinary scabies (OS)	Crusted scabies (CS)
Skin cellular responses	Mostly CD4+ T cells, eosinophils and macrophages [24]	Mostly CD8+ T cells, increased γδ+ T cells, eosinophils and few macrophages [14, 24, 35, 88]
Blood cell responses	T and B cells and T-cell subsets within normal ranges	T and B cells and T-cell subsets within normal ranges. Increased γδ+ T cells, eosinophilia [24, 88]
Th1/Th2 responses	Th1 mediated with increased production of Th1 cytokines IFN-γ, IL-2 and TNF-α [35, 46, 51]. Increased production of IL-10 [51]	Th2 mediated with increased production of Th2 cytokines IL-4, IL-5 and IL-13 [14, 35, 46]. Increased production of Th17 cytokines IL-17, IL −23 [46, 88]. Decreased production of IL-10 [24, 35]
Systemic Ig responses	Variable reports of elevated levels of total IgG, IgE, IgA and IgM. Increased levels of scabies-specific IgE, IgG and IgA [24, 35]	Increased levels of total IgG, IgG1, IgG3, IgG4, IgE and IgA. Elevated levels of scabies specific IgG4, IgE and IgA [24, 35]