Table 2.
Blood chemistry during chronic i.c.v. infusion of NPGL or the antibody against NPGL.
| A. Blood chemistry during chronic i.c.v. infusion of NPGL under high calorie diet. | ||
|---|---|---|
| CTL | NPGL | |
| Glucose (mg/dl) | 138 ± 5.7 | 135 ± 2.5 |
| Free Fatty Acid (mEq/l) | 0.526 ± 0.043 | 0.56 ± 0.066 |
| Triglyceride (mg/dl) | 101 ± 13.2 | 149 ± 20.9† |
| Cholesterol (mg/dl) | 99.0 ± 5.1 | 120.4 ± 5.3* |
| Insulin (ng/ml) | 2.53 ± 0.45 | 6.03 ± 1.22* |
| Leptin (ng/ml) | 8.76 ± 1.0 | 17.07 ± 1.6*** |
| B. Blood chemistry during chronic i.c.v. infusion of NPGL under normal chow. | ||
|---|---|---|
| CTL | NPGL | |
| Glucose (mg/dl) | 123 ± 7.0 | 128 ± 7.2 |
| Free Fatty Acid (mEq/l) | 0.276 ± 0.017 | 0.289 ± 0.017 |
| Triglyceride (mg/dl) | 73.0 ± 4.5 | 101.7 ± 11.6† |
| Cholesterol (mg/dl) | 66.5 ± 2.1 | 67.5 ± 3.4 |
| Insulin (ng/ml) | 4.51 ± 0.26 | 4.87 ± 0.33 |
| Leptin (ng/ml) | 8.84 ± 1.4 | 7.93 ± 0.70 |
| Corticosterone (ng/ml) | 523 ± 3.6 | 519 ± 1.4 |
| C. Blood chemistry during chronic i.c.v. infusion of the antibody against NPGL under high calorie diet. | ||
|---|---|---|
| CTL | NPGL-Ab | |
| Glucose (mg/dl) | 134 ± 2.38 | 137 ± 1.84 |
| Free Fatty Acid (mEq/l) | 0.529 ± 0.078 | 0.479 ± 0.048 |
| Triglyceride (mg/dl) | 129 ± 14.6 | 118 ± 18.8 |
| Cholesterol (mg/dl) | 111.9 ± 3.7 | 98.5 ± 4.7* |
| Insulin (ng/ml) | 2.23 ± 0.29 | 2.53 ± 0.33 |
| Leptin (ng/ml) | 9.14 ± 0.85 | 7.24 ± 0.51† |
| D. Blood chemistry during chronic i.c.v. infusion of NPGL under macronutrient diet. | ||
|---|---|---|
| CTL | NPGL | |
| Glucose (mg/dl) | 116 ± 4.4 | 124 ± 4.4 |
| Free Fatty Acid (mEq/l) | 0.359 ± 0.034 | 0.416 ± 0.042 |
| Triglyceride (mg/dl) | 74.4 ± 6.4 | 97.7 ± 7.8* |
| Cholesterol (mg/dl) | 99.7 ± 3.5 | 90.8 ± 5.5 |
| Insulin (ng/ml) | 1.94 ± 0.16 | 3.05 ± 0.68 |
| Leptin (ng/ml) | 3.92 ± 0.32 | 6.24 ± 0.33*** |
†p <0.1, *p<0.05, ***p<0.005.