Table 3. Cox proportional hazards model results for evaluating the risk of mortality in lung transplant candidates with interstitial lung disease (n = 77).
| Univariate analysis | Hazards ratio | 95%CI | p-value | ||
| Age, years | 1.02 | 0.99 | – | 1.05 | 0.27 |
| Male gender | 0.82 | 0.46 | – | 1.46 | 0.49 |
| IPF diagnosis | 0.82 | 0.45 | – | 1.50 | 0.52 |
| BMI, kg/m2 | 0.94 | 0.88 | – | 0.996 | 0.04 |
| Ever smoker | 0.93 | 0.52 | – | 1.66 | 0.81 |
| Pulmonary hypertension | 1.16 | 0.60 | – | 2.23 | 0.66 |
| History of acute exacerbation | 1.39 | 0.69 | – | 2.81 | 0.36 |
| History of pneumothorax | 1.26 | 0.69 | – | 2.31 | 0.45 |
| %FVC, per 10%* | 0.78 | 0.64 | – | 0.96 | 0.02 |
| %DLCO, per 10%† | 0.60 | 0.40 | – | 0.90 | 0.01 |
| 6MWD, per 10m | 0.97 | 0.95 | – | 0.99 | < 0.01 |
| Oxygen flow ≥2L/min at 6MWT | 2.33 | 1.28 | – | 4.25 | < 0.01 |
| GAP stage III | 2.55 | 1.07 | – | 6.04 | 0.03 |
| Multivariate analysis | Hazards ratio | 95%CI | p-value | ||
| Model 1 | |||||
| BMI, kg/m2 | – | – | – | ||
| %FVC, per 10% | – | – | – | ||
| 6MWD, per 10m | 0.97 | 0.95 | – | 0.99 | < 0.01 |
| Oxygen flow ≥2L/min at 6MWT | – | – | – | ||
| Model 2 | |||||
| BMI, kg/m2 | – | – | – | ||
| 6MWD, per 10m | 0.97 | 0.95 | – | 0.99 | < 0.01 |
| Oxygen flow ≥2L/min at 6MWT | – | – | – | ||
| GAP stage III | – | – | – | ||
CI, confidence interval; IPF, idiopathic pulmonary fibrosis; BMI, body mass index; ILD, interstitial lung disease; %FVC, percent predicted forced vital capacity; %DLCO, percent predicted diffusing capacity of the lung for carbon monoxide; 6MWD, 6-min walking distance; 6MWT, the 6-min walk test; GAP stage, gender-age-physiology stage.
*n = 71
†n = 50.