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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Biomaterials. 2017 May 10;137:1–10. doi: 10.1016/j.biomaterials.2017.05.010

Fig. 8. Protein secretion is differentially regulated by MAPK signaling pathway in 5% versus 10% hydrogels.

Fig. 8

Following encapsulation in 5% and 10% hydrogels, AFs were treated with ERK-1/2 pathway inhibitor PD98059 (10 µmol/L), the p38 inhibitor SB203580 (10 µmol/L), or the JNK inhibitor SP600125 (10 µmol/L). After 3 days of culture, production of (A) MCP-1, (B) IL-6, (C) VEGF, and (D) MMP-2 by AFs encapsulated in 5% and 10% hydrogels was examined. * represents significance from DMSO-treated control gels (p<0.05 by ANOVA with Tukey HSD). N=3.