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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: J Neurochem. 2017 Jun 29;142(4):560–573. doi: 10.1111/jnc.14078

FIGURE 2. Role of AMPAR activity in homocysteine-induced neuronal cell death.

FIGURE 2

Neuronal cultures were treated with L-homocysteine (50 μM, 18 h) in the absence or presence of NBQX (10 μM) or CNQX (50 μM) that were added 30 min after the onset of L-homocysteine treatment and then stained with Hoechst 33342, 18 h later. Representative photomicrographs show pyknotic DNA stained with Hoechst 33342 (indicated with arrows). Percentage of neurons with pyknotic nuclei is represented as mean ± SEM (n = 1500 cells/condition from 4 experiments). *p < 0.001 from control; #p < 0.05 from 18 h homocysteine treatment.