Figure 1.

Effect of non-viable Lactobacillus rhamnosus CRL1505 (HK1505) and its peptidoglycan (PG1505) on lung tissue damage induced by the nasal administration of the viral pathogen-associated molecular pattern poly(I:C). Infant mice were nasally primed with HK1505 or PG1505 during two consecutive days and then challenged with three once-daily doses of poly(I:C) (A). Non-treated infant mice challenged with poly(I:C) were used as controls. 2 days after the last poly(I:C) administration lung wet:dry weight ratio (B), lactate dehydrogenase (LDH) activity and, albumin and protein concentrations in bronchoalveolar lavages (BAL) (C) were determined. The results represent data from three independent experiments. Significant differences between treated and control groups, *P < 0.05, **P < 0.05.