Figure 4.

In vivo studies using [¹¹C] D-Met and [¹¹C] L-Met a murine myositis model (n = 4 for each condition studied). In all cases the site of live bacterial inoculation is denoted by a red arrow, while the site of 10X heat-killed bacterial inoculation is denoted by a white arrow. (A) [¹¹C] D-Met studies in E. coli and S. aureus-infected animals. Representative images show marked uptake in areas corresponding to live bacterial injection (left deltoid), in contrast to sterile inflammation (right deltoid) and normal muscle. ROI analysis of E. Coli and S. aureus [¹¹C] D-Met cohorts, corrected using normal muscle uptake. (B) [¹¹C] L-Met studies in E. coli and S. aureus. There is no observable difference in signals from the left (infected) and right (sterile inflammation) deltoid muscles. ROI analysis of E. Coli and S. aureus [¹¹C] L-Met cohorts, showing no significant difference in accumulation between infection and sterile inflammation.