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. 2017 Aug 11;7:7961. doi: 10.1038/s41598-017-08315-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pan-metalloproteinase inhibitors do not affect adhesion or cell death of DRG neurons. (a) A TUNEL assay was performed in embryonic DRG neurons (E18-19) seeded on a PLL substrate and treated with a vehicle control (DMSO), metalloproteinase inhibitors (BB-94 and GM6001) or GM-I. Neurons were stained with anti-βIII tubulin, Hoechst and TUNEL. As a positive control for the TUNEL assay, neurons were pretreated with a DNA nuclease. (b,c) Total number of apoptotic neurons (b) and total neurons (c) present after indicated treatments. For TUNEL, the data are shown as a percentage of TUNEL-positive neurons. For total number of neurons, data have been normalized to control DMSO. N = 4 from independent cultures. Data are shown as mean + S.E.M. Scale bar, 100 μm.