Table 4.

Clinical correlations of anti-Hp antibody reactivity to individual antigens and features of multiple sclerosis.

		Age at onset	EDSS	Disease duration	PI = EDSS/duration	Relapses	Anti-Hp ELISA Units	CagA	VacA	p75	p67	p66-UreB	p54-flagellin	p50	p41	p33	p30	p29-UreA	p26	p19	p17
Age	R	0.787	0.497	0.530											0.342	0.267
	p	0.000	0.000	0.000	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	0.008	0.039	ns	ns	ns	ns	ns
Age at onset	R				0.334	−0.273		.								0.291	0.253
	p		ns	ns	0.010	0.038	ns	ns	ns	ns	ns	ns	ns	ns	ns	0.024	0.051	ns	ns	ns	ns
EDSS	R			0.522									0.310					0.364	0.392
	p			0.000	ns	ns	ns	ns	ns	ns	ns	ns	0.017	ns	ns	ns	ns	0.005	0.002	ns	ns
Disease duration	R				−0.326	0.243									0.246
	p				0.012	0.066	ns	ns	ns	ns	ns	ns	ns	ns	0.058	ns	ns	ns	ns	ns	ns
PI	R
	p					ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns
Relapses	R																	0.242	0.274		0.262
	p						ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	0.067	0.037	ns	0.047
Anti-Hp ELISA Units	R								0.286	0.312	0.315					0.376	0.375		0.482		0.282
	p							ns	0.027	0.015	0.014	ns	ns	ns	ns	0.003	0.003	ns	0.000	ns	0.029

R represents Pearson correlation coefficient. p represents p value (2 tailed) associated with the correlation. p-values < 0.05 are shown in bold; p-values with a statistical tendency (<0.1) are also shown. Abbreviations: CagA, protein from cytotoxin-associated gene A; EDSS, extended disability status scale; Hp, Helicobacter pylori; ns, not significant; PI, Progression Index; UreA, urease A; UreB, urease B; VacA, vacuolating cytotoxin A.