Skip to main content
. 2017 Aug 11;7:7986. doi: 10.1038/s41598-017-08208-2

Figure 1.

Figure 1

MCS effects on neuropathic pain. (A) Development of mechanical allodynia after nerve injury. On days 1, 4, 7, and 14 after surgery, neuropathic rats showed a significantly decreased mechanical withdrawal threshold compared with the sham-operated group (B) Comparison of the daily pre-MCS behavioral tests. The mechanical threshold changes between groups were compared with the daily pre-MCS session. From the second MCS, the withdrawal threshold gradually increased until the last day of MCS. (C) Comparison of the daily post-MCS behavioral tests. The mechanical threshold changes between groups were compared with the daily post-MCS session. The withdrawal thresholds were immediately elevated after MCS and gently increased. (D) Comparison of the withdrawal threshold changes at daily pre/post-MCS in neuropathic pain. After MCS, the mechanical threshold became insensitive and the thresholds increased with daily MCS. When comparing the daily pre/post-MCS, the thresholds of the post-MCS were higher than the pre-MCS. (E) Comparison of the withdrawal latency changes according to repetitive MCS. The latency was immediately elevated after MCS and gradually increased after repetitive MCS (Daily pre-MCS: ρ value = 0.753, P = 0.03; Daily post-MCS: ρ value = 0.28, P = 0.13). *P < 0.05 compared with NP + sham MCS.