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. 2017 Aug 11;7:7986. doi: 10.1038/s41598-017-08208-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effects of ZIP injection on neuropathic rats and MCS on naïve rats. (A) The effects of ZIP injection on neuropathic rats. In the behavioral test after 14 days in the NP rats, the withdrawal thresholds did not significantly change between the duration of ZIP injection and the end of ZIP injection days. (B) For evaluation of the effects of MCS on the control (non-injured) rats, the mechanical thresholds were measured daily pre- and post-MCS. In the comparison of pre- and post-MCS, the withdrawal thresholds did not change over the duration of MCS.