Table 4.
Relationship between Tumor Position and Gene Mutation, Protein Expression Levels in 289 Colorectal Cancer Patients.
| Gene Mutation & Expression Level | Right-sided colon cancer (n = 57) | Left-sided colon cancer (n = 87) | Rectal cancer (n = 145) | Total (n = 289) | P1* | P2* | P3* | P4* | P5* |
|---|---|---|---|---|---|---|---|---|---|
| KRAS | 0.685 | 0.637 | 0.392 | 0.673 | 0.464 | ||||
| Wild | 27 | 42 | 59 | 128 | |||||
| Mutant | 16 | 30 | 48 | 94 | |||||
| Unknown | 14 | 15 | 38 | 67 | |||||
| BRAF | 0.074 | 0.144 | 0.068 | 0.769 | 0.202 | ||||
| Wild | 39 | 70 | 106 | 215 | |||||
| Mutant | 3 | 1 | 1 | 5 | |||||
| Unknown | 15 | 16 | 38 | 69 | |||||
| MLH1 | 0.735 | 0.614 | 0.860 | 0.509 | 0.701 | ||||
| Defect | 6 | 13 | 17 | 36 | |||||
| Normal | 44 | 67 | 114 | 225 | |||||
| Unknown☆ | 7 | 7 | 14 | 28 | |||||
| MSH2 | 0.898 | 0.641 | 0.786 | 0.792 | 0.974 | ||||
| Defect | 2 | 2 | 4 | 8 | |||||
| Normal | 50 | 80 | 127 | 257 | |||||
| Unknown☆ | 5 | 5 | 14 | 24 | |||||
| MSH6 | 0.989 | 0.886 | 0.945 | 0.920 | 0.972 | ||||
| Defect | 4 | 6 | 10 | 20 | |||||
| Normal | 46 | 76 | 120 | 242 | |||||
| Unknown☆ | 7 | 5 | 15 | 27 | |||||
| PMS2 | 0.497 | 0.388 | 0.828 | 0.268 | 0.566 | ||||
| Defect | 1 | 0 | 2 | 3 | |||||
| Normal | 49 | 79 | 128 | 256 | |||||
| Unknown☆ | 7 | 8 | 15 | 30 | |||||
| β-Tubulin III | 0.452 | 0.280 | 0.221 | 0.957 | 0.563 | ||||
| (−)~(+) | 8 | 27 | 52 | 87 | |||||
| (++)~(+++) | 5 | 8 | 15 | 28 | |||||
| Unknown☆ | 44 | 52 | 78 | 174 | |||||
| TOPIIα | 0.223 | 0.088 | 0.317 | 0.308 | 0.818 | ||||
| (−)~(+) | 41 | 54 | 96 | 191 | |||||
| (++)~(+++) | 11 | 29 | 38 | 78 | |||||
| Unknown☆ | 5 | 4 | 11 | 20 | |||||
| P53 | 0.660 | 0.366 | 0.607 | 0.585 | 0.902 | ||||
| (−)~(+) | 26 | 36 | 63 | 125 | |||||
| (++)~(+++) | 24 | 46 | 69 | 139 | |||||
| Unknown☆ | 7 | 5 | 13 | 25 | |||||
| Ki67 | 0.875 | 0.922 | 0.746 | 0.619 | 0.612 | ||||
| (−)~(+) | 3 | 5 | 6 | 14 | |||||
| (++)~(+++) | 51 | 79 | 129 | 259 | |||||
| Unknown☆ | 3 | 3 | 10 | 16 | |||||
| TOPIIα index (%) | 19 (0–70) | 27 (0–90) | 25 (0–90) | 20 (0–90) | 0.015 | 0.007 | 0.010 | 0.635 | 0.322 |
| P53 index (%) | 38 (0–95) | 46 (0–95) | 42 (0–95) | 45 (0–95) | 0.311 | 0.138 | 0.430 | 0.323 | 0.765 |
| Ki67 index (%) | 68 (5–90) | 69 (0–100) | 69 (10–90) | 70 (0–100) | 0.651 | 0.439 | 0.878 | 0.412 | 0.622 |
#RSCC: Right-sided colon cancer; ▴LSCC: Left-sided colon cancer; *P1: comparison of three group; P2: RSCC vs. LSCC; P3: RSCC vs. rectal; P4: LSCC vs. rectal; P5:colon vs. rectal; ☆All of the “Unknown” groups were not taken into analysis in this table.