Table 5.

Univariate Analyses of Factors Associated With Progression Free Survival (n = 289).

Variables	95%CI	P
Tumor Position (Right vs. Left&Rectum)#	0.612 (0.407–0.919)	0.018
Gender (Male vs. Female)	1.428 (0.720–2.833)	0.308
Age (<65 y vs. >=65 y)	1.098 (0.549–2.196)	0.791
Preoperative chemotherapy (No vs. Yes)	3.295 (1.332–8.153)	0.010
Preoperative radiation (No vs. Yes)	0.048 (0–1858.733)	0.573
Combined Resection (No vs. Yes)	2.087 (0.863–5.046)	0.102
Open or Laparoscopic (Open vs. Laparoscopic)	0.611 (0.275–1.357)	0.226
Gross Type (Protruding vs. (Ulcerative, Infiltratie))	1.919 (0.581–6.342)	0.285
Circumference (<1/2 vs. >=1/2)	1.037 (0.925–1.162)	0.538
Differentiation (Well&Moderate vs. Poor)	3.161 (1.560–6.407)	0.001
T stage ((T1-T2) vs. (T3-T4))	5.586 (1.338–23.317)	0.018
N (N0 vs. (N1-N2))	3.586 (1.673–7.686)	0.001
M (M0 vs. M1)	4.356 (2.211–8.579)	0.000
TNM ((1–2) vs. (3–4))	2.673 (1.775–4.026)	0.000
CEA (<5ng/mL vs. >=5ng/mL)	2.007 (1.051–3.833)	0.035
CA199 (<37 U/mL vs. >=37 U/mL)	2.225 (1.106–4.473)	0.025
KRAS (Wild vs. Mutant)	0.945 (0.842–1.061)	0.340
BRAF (Wild vs. Mutant)	0.954 (0.856–1.064)	0.397
Tumor Deposit (No vs. Yes)	3.270 (1.659–6.445)	0.001
Perineural Invasion (No vs. Yes)	2.862 (1.414–5.789)	0.003
Vascular Invasion (No vs. Yes)	3.166 (1.556–6.444)	0.001
MLH1 (Defect vs. Normal)	0.966 (0.837–1.114)	0.619
MSH2 (Defect vs. Normal)	0.934 (0.785–1.111)	0.438
MSH6 (Defect vs. Normal)	0.905 (0.760–1.078)	0.262
PMS2 (Defect vs. Normal)	0.907 (0.755–1.090)	0.298
β-Tubulin III ((−)~(+) vs. (++)~(+++))	1.016 (0.928–1.111)	0.735
TOPIIα ((−)~(+) vs. (++)~(+++))	0.930 (0.748–1.158)	0.518
P53 ((−)~(+) vs. (++)~(+++))	0.938 (0.774–1.137)	0.514
Ki67 ((−)~(+) vs. (++)~(+++))	1.001 (0.811–1.237)	0.991

^#Right-sided colon cancer vs. Left -sided colon cancer & Rectal cancer.