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. 2017 Aug 11;7:7996. doi: 10.1038/s41598-017-08237-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Synaptic responses during higher-frequency repetitive stimulation in juvenile mice. (a) The time course of EPSPs during 20-Hz trains in CA1 synapses in juvenile WT (open circles:○) and KI (closed circles:●) mice. During 20-Hz stimulation, the depression of EPSPs in the early phase was similar in WT and KI mice. In contrast, the steady-state responses in the late phase were significantly larger in KI mice compared with WT mice. (b) The cumulative plot of EPSP amplitudes during 20-Hz trains, which were normalized to those of the baseline EPSP, is shown. The broken lines represent the regression lines fitted to the last 10 points (from the 191st to the 200th pulse) of EPSPs in KI (closed circles:●) and WT (open circles:○) mice.