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. 2017 Aug 11;7:7992. doi: 10.1038/s41598-017-08703-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model of the Sec23A/Sec24D-mediated HSC activation. (1) Cytokines such as TGF-β activate CREB3L2/BBF2H7. (2) Activated p60 CREB3L2/BBF2H7 upregulates the transcription of Sec23A and Sec24D. (3) An activated factor(s) is transported by a COPII-dependent process for HSC activation.