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. 2017 Aug 11;7:7865. doi: 10.1038/s41598-017-07609-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative pH_e maps from BIRDS in untreated (A) and TMZ treated (B) rats bearing U251 tumors. (i) The T₂-weighted images identify the tumor boundary (tumor = blue outline; brain = orange outline). (ii) CSI data for corresponding slice in (i) shows varying TmDOTP⁵⁻ levels throughout the brain. (iii) Quantitative pH_e maps were obtained using multiple TmDOTP⁵⁻ peaks and the intratumoral and peritumoral pH_e average values and their standard deviations (SDs) are indicated. In untreated rats, the tumor is larger and the intratumoral pH_e is acidic and spreads beyond the tumor boundary. In treated rats, the tumor is smaller and the intratumoral pH_e is near neutral with lower pH_e localized within the tumor boundary.