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. 2017 Aug 11;7:7958. doi: 10.1038/s41598-017-08483-z

Figure 6.

Figure 6

Combined effects of inhibitor of MEK/Erk signaling pathway and PD-L1 Ab on NK cytotoxicity. The susceptibility of cisplatin-resistant lung cancer cells to cytotoxic action of primary NK cells was enhanced when the inhibitor of MEK/Erk signaling pathway and PD-L1 Ab were both present. (A,B) (A) NK cytotoxicity tests (primary NK cells) of A549CisR and H157CisR cells. (B) A549P and H157P cells in the presence of PD-L1Ab alone, U0126 alone, vs. both present in the co-culture of tumor cells/primary NK cells. (C) A cartoon depicting tumor cell and NK cell interactions through PD-L1/PD-1 and NKG2D ligands/NKG2D axis. *p < 0.05, **p < 0.01, ***p < 0.001.