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. 2017 Aug 11;7:7872. doi: 10.1038/s41598-017-08447-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypoxia and stemness: Exposure of pancreatic cancer cells to hypoxia resulted in increased expression of stemness genes (A). In addition, Aldh activity, a known phenotypic marker of cancer stem cells, measured by Aldefluor was increased upon exposure to hypoxia or its chemical mimetics (B). In addition, upon activation of hypoxia mediated signaling, increased drug transporter activity was observed (C). Treatment with Minnelide decreased stemness in pancreatic cancer cells.