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. 2017 Aug 11;7:7901. doi: 10.1038/s41598-017-08148-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Subtype specific miRNAs can be either oncogenic or representative for the differentiation arrest of lymphoblasts. (a + c) Box plots showing the expression of the immature T-ALL specific miRNAs hsa-miR-126-5p and hsa-miR-222-3p in the immature T-ALL patients and the thymocyte subsets. (b + d) Box plots showing the expression of the TAL-R T-ALL specific miRNAs hsa-miR-16-2-3p and hsa-miR-450b-5p in the TAL-R T-ALL patients and the thymocyte subsets. *Significant difference with an adjusted p-value < 0.05; **significant difference with an adjusted p-value < 0.001.