Table 3.
Genotypes and alleles distributions of five selected variants in ET and controls stratified by age at onset.
| Variants | Genotypes/Alleles | EOET/LOET (118/100) (%) | HC<40/HC ≥ 40 (203/112) (%) | p OR(95%CI)a | p OR(95%CI)b |
|---|---|---|---|---|---|
| rs10937625 | CC | 2(1.7)/1(1.0) | 6(3.0)/9(8.0) | 0.997 1.00[0.61–1.65] | 0.002 0.41[0.24–0.71] |
| TC | 28(23.7)/24(24.0) | 53(26.1)/38(33.9) | |||
| TT | 88(74.6)/75(75.0) | 144(70.9)/65(58.0) | |||
| C | 32(13.6)/26(13.0) | 65(16.0)/56(25.0) | 0.997 1.00[0.78–1.29] | 0.001 0.64[0.49–0.83] | |
| T | 204(86.4)/174(87.0) | 341(84.0)/168(75.0) | |||
| rs17590046 | CC | 0(0)/2(2.0) | 4(2.0)/0(0) | 0.360 0.75[0.40–1.40] | 0.090 1.91[0.91–4.03] |
| TC | 18(15.3)/15(15.0) | 30(14.8)/13(11.6) | |||
| TT | 100(84.7)/83(83.0) | 169(83.3)/99(88.4) | |||
| C | 18(7.6)/19(9.5) | 38(9.4)/13(5.8) | 0.344 0.86[0.62–1.18] | 0.084 1.39[0.96–2.02] | |
| T | 218(92.4)/181(90.5) | 368(90.6)/211(94.2) | |||
| rs12764057 | GG | 7(5.9)/7(7.0) | 13(6.4)/5(4.5) | 0.769 0.94[0.63–1.41] | 0.059 1.57[0.98–2.53] |
| TG | 47(39.8)/41(41.0) | 80(39.4)/35(31.3) | |||
| TT | 64(54.2)/52(52.0) | 110(54.2)/72(64.3) | |||
| G | 61(25.8)/55(27.5)) | 106(26.1)/45(20.1) | 0.770 0.97[0.79–1.19] | 0.058 1.26[0.99–1.59] | |
| T | 175(74.2)/145(72.5) | 300(73.9)/179(79.9) | |||
| rs10822974 | AA | 19(16.1)/17(17.0) | 53(26.1)/26(23.2) | 0.497 0.88[0.62–1.26] | 0.123 0.73[0.49–1.09] |
| GA | 67(56.8)/49(49.0) | 90(44.3)/58(51.8) | |||
| GG | 32(27.1)/34(34.0) | 60(29.6)/28(25.0) | |||
| A | 105(44.5)/83(41.5) | 196(48.3)/110(49.1) | 0.495 0.94[0.79–1.12] | 0.124 0.86[0.70–1.04] | |
| G | 131(55.5)/117(58.5) | 210(51.7)/114(50.9) | |||
| rs7903491 | GG | 20(16.9)/24(24.0) | 32(15.8)/14(12.5) | 0.406 1.17[0.81–1.68] | 0.089 1.41[0.95–2.09] |
| AG | 63(53.4)/42(42.0) | 97(47.8)/51(45.5) | |||
| AA | 35(29.7)/34(34.0) | 74(36.5)/47(42.0) | |||
| G | 103(43.6)/90(45.0) | 161(39.7)/79(35.3) | 0.412 1.08[0.90–1.29] | 0.077 1.20[0.98–1.47] | |
| A | 133(56.4)/110(55.0) | 245(60.3)/145(64.7) |
P values were determined using binary logistic regression adjusted for age and gender, and p values <0.05 indicate significant differences between two groups. Abbreviations: ameans EOET compared with healthy controls <40 years. bmeans LOET compared with healthy controls ≥40 years. ET: essential tremor; HC: healthy controls; EOET: early onset essential tremor related to age at onset <40 years; LOET: late onset essential tremor related to age at onset ≥40 years.