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. 2017 Aug 11;7:7894. doi: 10.1038/s41598-017-08480-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diet-induced obesity in exercise-trained Atg7^h&mKO mice. (a) Atg7 mRNA and immunoblot representative images of the mean value for select autophagy and ubiquitinated proteins (UB) in muscle and heart (n = 11–15). (b) GTT (n = 14). (c) Distance run and blood lactate before (Pre) and after (Post) the endurance exercise capacity test (n = 11). (d) Body weight quantification and percentage change during the intervention (n = 8–11). (e) Muscle (Soleus-SOL, Plantaris-PL, Gastrocnemius-GA) and adipose (BAT and eWAT) masses normalized to tibia length (TL) and body weight (BW) (n = 6–11). (f) Average daily caloric intake, and feed efficiency (n = 6). (g) Weekly average of daily voluntary running activity, and total running distance during the intervention (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 ****P < 0.0001 in comparison to all other groups, unless otherwise represented; ^Φ P < 0.05 both Atg7^fl/fl-HFD&EX and Atg7^h&mKO-HFD&EX in comparison to respective HFD only, sedentary groups.