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. 2017 Aug 11;7:7887. doi: 10.1038/s41598-017-07653-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental cases considered in our study. The first column shows isolated cells seeded at a low density to avoid cell–cell interaction. The second column represents cells in the monolayer. The substrate was isotropic in the upper row, whereas in the second row, nanofibres were added. Cardiomyocytes are shown in yellow tints, whereas fibroblasts are shown in blue tints. This image was based on immunohistochemical data but was refined for illustrative purpose.