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. 2017 Aug 11;7:7887. doi: 10.1038/s41598-017-07653-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Examples of simulations for four seeding conditions. Cardiomyocytes are shown in yellow tints, whereas fibroblasts are shown in blue tints. Here the proportions of the cells of each type were 50%. Black lines in (d) show the borders that constrain the anisotropic monolayer. In (c) and (d), grey horizontal lines show nanofibres.