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. Author manuscript; available in PMC: 2017 Oct 24.
Published in final edited form as: Nat Neurosci. 2017 Apr 24;20(6):854–863. doi: 10.1038/nn.4554

Figure 6. VIP neuron activation improved dmPFC coding of action plan.

Figure 6

(a) Spiking activity of example significant Go-preferring (Cells 1 and 2) and NG-preferring cells (Cells 3 and 4) with or without VIP neuron activation. (b) Difference between Go and No-Go activity during the delay period in laser on vs. laser off trials, for significant Go-preferring (blue) and NG-preferring (magenta) neurons. The difference divided by their sum increased in Go-preferring cells (P = 1.1 × 10−9, paired t-test) and decreased in NG-preferring cells (P = 0.0030) with VIP neuron activation. (c) VIP neuron activation increased the Euclidean distance between Go and No-Go activities. The black horizontal bars on the top indicate the analysis periods including baseline (1 s before the beginning of sample), sample, delay, and post-delay (0.5 s after the end of delay) periods. The difference in the Euclidean distance was significant for all analysis periods except for the baseline period (P = 0.49; bootstrap). *P = 0.0060; **P = 0.0002; ***P = 0 (bootstrap); Shading and error bars, 95% confidence intervals (bootstrap).