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. Author manuscript; available in PMC: 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 17;545(7655):477–481. doi: 10.1038/nature22350

Figure 2. Optogenetic activation of GABAPOA or VGLUTPOA→TMN neurons promotes wakefulness.

Figure 2

a, Schematic for optogenetic stimulation of GABAPOA neurons. Mouse brain figure adapted with permission from ref. 31. b, Two example trials. Blue shading, laser stimulation (10 Hz, 120 s). c, Percentage of time in wake, NREM, or REM state, averaged from 5 mice (P<0.0001 for increased wakefulness, bootstrap). Shading, 95% CI. d–f, Similar to a–c, for optogenetic stimulation of VGLUTPOA→TMN neurons (P<0.0001 for increase in wakefulness, bootstrap, n=4 mice).