Skip to main content
. 2017 Aug 1;174(17):2929–2940. doi: 10.1111/bph.13924

Figure 2.

Figure 2

CUMS reduced baclofen (Bac)‐induced current in PVN‐CRH neurons. (A) Original recordings show currents elicited by a bath application of 10 μM baclofen to eGFP‐tagged PVN‐CRH neurons in brain slices treated with or without AP5 (50 μM for 1 h) in unstressed and CUMS rats. Note undetectable currents after the application of 10 μM baclofen in the presence of GIRK channel blocker tertiapin‐Q or GABAB receptor blocker CGP55845. (B) Summary data show the density of baclofen ‐induced currents recorded in PVN‐CRH neurons, with or without AP5 treatment, in unstressed and CUMS rats. These data were collected from unstressed rats (vehicle: n = 12 neurons in eight rats, and AP5: n = 12 neurons in seven rats) and CUMS rats (vehicle: n = 12 neurons in seven rats, and AP5: n = 13 neurons in eight rats). Data are means ± SEM. *P < 0.05, significantly different from values in unstressed rats.