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. 2017 Jul 26;174(17):2912–2928. doi: 10.1111/bph.13921

Figure 6.

Figure 6

Effects of DKS26 on hepatic lipid accumulation and metabolism related genes in STZ‐induced and db/db diabetic mice. STZ‐induced diabetic mice: (A) and (B) hepatic TG and TC contents (normal control n = 5, STZ control n = 7 and other groups n = 8), (C) liver sections by Oil Red O staining (200×, scale bar 100 μm), (D) hepatic lipid metabolism related SREPB‐1c, FAS, PPAR‐α and CPT1 mRNA levels (vs. β‐actin, normal control n = 5 and other groups n = 6). Db/db diabetic mice: (E) and (F) hepatic TG and TC contents (db/db and metformin control n = 7 and other groups n = 8), (G) liver sections by Oil Red O staining (100×, scale bar 100 μm), (H) hepatic lipid metabolism related SREPB‐1c, FAS, PPAR‐α and CPT1 mRNA levels (vs. β‐actin, n = 6). OA represents oleanolic acid; MET represents metformin. Values are expressed as mean ± SEM. Compared with normal control group, # P < 0.05,; compared with model control group (STZ control or db/db control), * P < 0.05.