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. 2017 Aug 10;11:241. doi: 10.3389/fncel.2017.00241

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Copyright © 2017 Basil, Sim, Lim, Lin, Chan, Engelender and Lim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AF-6 overexpression rescues the disease phenotypes of pink1 null flies. (A) Survival curve depicting the percentage of surviving flies between pink1 knockout (PINK1B9) flies in the absence and presence of AF-6 overexpression with 24B GAL4 driver (UAS-AF-6/+; 24B > PINK1KO) up to 70 days. (B) Flight assay showing the percentage of pink1 knockout flies that are capable of flying in the absence and presence of AF-6 overexpression in muscles using the 24B GAL4 driver at day 3 post eclosion. (C) TEM images of indirect flight muscles of pink1 knockout flies in the absence and presence of AF-6 overexpression. *p < 0.05; unpaired student’s t test.