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. 2017 Aug 10;8:968. doi: 10.3389/fimmu.2017.00968

Figure 1.

Figure 1

Comparison of the frequencies of early secretory antigenic target (ESAT)-6/culture filtrate protein (CFP)-10-, Mycobacterium tuberculosis (Mtb) lysate-, or cytomegalovirus virus (CMV)-specific IFNγ+ CD4+ T cells in individuals with distinct HIV and tuberculosis (TB) disease status. (A) Representative flow cytometry plots of the expression of IFNγ from CD4+ and CD3+ CD4− T cells after stimulation with ESAT-6/CFP-10, Mtb lysate and CMV antigens in one individual from each clinical group. NS corresponds to unstimulated PBMC. The frequency of IFNγ-producing cells expressed as a percentage of the total CD3+ CD4+ or total CD3+ CD4− T cell population is indicated. (B) Frequency of IFNγ-producing CD4+ T cell in response to ESAT-6/CFP-10, Mtb lysate or CMV in HIV−/latent tuberculosis infection (LTBI) (n = 20), HIV−/active TB (aTB) (n = 20), HIV+/LTBI (n = 21), and HIV+/aTB (n = 20). Bar represents the median. Symbols shown below the horizontal dashed line correspond to non-responders. Statistical comparisons were performed using a Mann–Whitney t-test.