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. 2017 Aug 10;11:53. doi: 10.3389/fncir.2017.00053

Figure 2.

Figure 2

Propranolol treatment after CS-retrieval disrupted fear memory reconsolidation selectively in response to the same CS. (A) Schematic of the main experimental design. Twenty-four hours after the sequential fear conditioning paradigm (FS: 0.25 mA), propranolol was treated after CS-A or CS-B induced memory retrieval. Twenty-four hours after CS-retrieval, mice were tested for LTM to both CS-A and CS-B. (B–E) Selective impairment of fear memory reconsolidation to CS-A by propranolol treated after CS-A retrieval. (B,D) Curves of response to CS showed as the percentage time of freezing during each CS. (C,E) Freezing to CS-A or CS-B in average. n = 12 for Propranolol group; n = 11 for Ns group. *p < 0.05 vs. Ns treated group; #p < 0.05 between indicated group. (F–I) Selective impairment of fear memory reconsolidation to CS-B by propranolol treated after CS-B retrieval. (F,H) Curves of response to CS showed as the percentage time of freezing during each CS. (G,I) Freezing to CS-A or CS-B in average. n = 8 for each group. **p < 0.01 vs. Ns treated group; ##p < 0.01 between indicated group.