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. 2017 Aug 10;10:250. doi: 10.3389/fnmol.2017.00250

Table 2.

Correlation between miR-140-3p expression and neuropsychiatric parameters.

ALL PATIENTS AND NCS
ΔCt vs. IQ ΔCt vs. YGTSS ΔCt vs. ADOS Communication ΔCt vs. ADOS Social interaction ΔCt vs. ADOS Imagination ΔCt vs. ADOS Repetitive and restricted behaviors
Spearman r 0.02 0.33 −0.13 −0.07 −0.17 NT
Pearson r NT NT NT NT NT −0.17
95% CI −0.18–0.21 0.15–0.50 −0.32–0.07 −0.27–0.12 −0.36–0.03 −0.35–0.02
two-sided p-value 0.86 0.0005 0.18 0.45 0.09 0.08
Is p < Bonferroni corrected α? N Y N N N N
Bonferroni-Holm adjusted p-value 1.00 0.008 1.00 1.00 1.00 1.00
Benjamini-Hochberg p-value (FDR 1%) 0.86 0.008 0.29 0.51 0.23 0.23
Number of XY Pairs 104 104 104 104 104 104
ASD PATIENTS AND NCS
ΔCt vs. ADOS Communication ΔCt vs. ADOS Social interaction ΔCt vs. ADOS Imagination ΔCt vs. ADOS Repetitive and restricted behaviors
Spearman r -0.27 -0.20 -0.31 NT
Pearson r NT NT NT -0.29
95% CI −0.51–0.003 −0.45–0.08 −0.53–−0.04 −0.51–−0.02
two-sided p-value 0.05 0.15 0.02 0.03
Is p < Bonferroni corrected α? N N N N
Bonferroni-Holm adjusted p-value 0.60 1.00 0.34 0.47
Benjamini-Hochberg p-value (FDR 1%) 0.18 0.29 0.18 0.18
Number of XY Pairs 55 55 55 55
TS PATIENTS AND NCS
ΔCt vs. YGTSS
Spearman r −0.03
95% CI −0.31–0.26
two-sided p-value 0.84
Is p < Bonferroni corrected α? N
Bonferroni-Holm adjusted p-value 1.00
Benjamini-Hochberg p-value (FDR 1%) 0.86
Number of XY Pairs 49
TS+ASD PATIENTS AND NCS
ΔCt vs. YGTSS ΔCt vs. ADOS Communication ΔCt vs. ADOS Social interaction ΔCt vs. ADOS Imagination ΔCt vs. ADOS Repetitive and restricted behaviors
Spearman r 0.21 0.17 0.15 0.17 0.20
95% CI −0.08–0.47 −0.12–0.43 −0.14–0.42 −0.12–0.44 −0.09–0.46
two-sided p-value 0.14 0.24 0.28 0.23 0.17
Is p < Bonferroni corrected α? N N N N N
TS+ASD PATIENTS AND NCS
ΔCt vs. YGTSS ΔCt vs. ADOS Communication ΔCt vs. ADOS Social interaction ΔCt vs. ADOS Imagination ΔCt vs. ADOS Repetitive and restricted behaviors
Bonferroni-Holm adjusted p-value 1.00 1.00 1.00 1.00 1.00
Benjamini-Hochberg p-value (FDR 1%) 0.29 0.33 0.35 0.33 0.29
Number of XY Pairs 50 50 50 50 50

We performed the analyses in both a general (Section 1) and a class-specific (Sections 2–4) manner. Either Pearson or Spearman r values from every analysis are reported. Bonferroni corrected α = 0.05/16 = 0.003. IQ, Intelligence Quotient; ADOS, Autism Diagnostic Observation Schedule; YGTSS, Yale Global Tic Severity Scale; 95% CI, 95% Confidence Interval; NT, Not Tested; N, no; Y, yes; FDR, False Discovery Rate.