Table 4.
Over-represented GO, DO and KEGG terms associated with CD38 in miR-140-3p-mediated regulatory network.
| Annotation Database | Term ID | Term description | BH adjusted p-value | Gene Ratio | Background Ratio |
|---|---|---|---|---|---|
| GO BP | GO:0048545 | response to steroid hormone | 2.94E-35 | 0.4337 | 0.0221 |
| GO BP | GO:0032355 | response to estradiol | 5.13E-08 | 0.1205 | 0.0070 |
| GO BP | GO:0070482 | response to oxygen levels | 4.53E-07 | 0.1566 | 0.0181 |
| KEGG | hsa05169 | Epstein-Barr virus infection | 3.36E-06 | 0.1884 | 0.0283 |
| GO BP | GO:0001101 | response to acid chemical | 7.61E-06 | 0.1325 | 0.0158 |
| GO BP | GO:0042493 | response to drug | 7.61E-06 | 0.1566 | 0.0238 |
| GO BP | GO:0002764 | immune response-regulating signaling pathway | 3.86E-05 | 0.1566 | 0.0294 |
| GO BP | GO:0051251 | positive regulation of lymphocyte activation | 4.72E-05 | 0.1205 | 0.0166 |
| GO BP | GO:0036293 | response to decreased oxygen levels | 5.76E-05 | 0.1205 | 0.0171 |
| GO BP | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 6.41E-05 | 0.1325 | 0.0217 |
| GO BP | GO:0002694 | regulation of leukocyte activation | 7.86E-05 | 0.1446 | 0.0269 |
| GO BP | GO:0002696 | positive regulation of leukocyte activation | 8.41E-05 | 0.1205 | 0.0180 |
| GO BP | GO:0002757 | immune response-activating signal transduction | 8.67E-05 | 0.1446 | 0.0274 |
| GO BP | GO:0050867 | positive regulation of cell activation | 9.75E-05 | 0.1205 | 0.0185 |
| GO BP | GO:0051249 | regulation of lymphocyte activation | 0.00012 | 0.1325 | 0.0238 |
| GO BP | GO:0050865 | regulation of cell activation | 0.00013 | 0.1446 | 0.0289 |
| GO BP | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 0.00015 | 0.1205 | 0.0197 |
| GO BP | GO:0001666 | response to hypoxia | 0.00025 | 0.1084 | 0.0166 |
| GO BP | GO:0032526 | response to retinoic acid | 0.00028 | 0.0723 | 0.0061 |
| GO BP | GO:0016049 | cell growth | 0.00048 | 0.1325 | 0.0289 |
| GO BP | GO:0007565 | female pregnancy | 0.00055 | 0.0843 | 0.0107 |
| GO BP | GO:0044706 | multi-multicellular organism process | 0.0010 | 0.0843 | 0.0121 |
| GO BP | GO:0050708 | regulation of protein secretion | 0.0015 | 0.1084 | 0.0226 |
| GO BP | GO:0001558 | regulation of cell growth | 0.0016 | 0.1084 | 0.0229 |
| GO BP | GO:0050851 | antigen receptor-mediated signaling pathway | 0.0017 | 0.0843 | 0.0134 |
| GO BP | GO:0032844 | regulation of homeostatic process | 0.0032 | 0.1084 | 0.0260 |
| GO BP | GO:0050670 | regulation of lymphocyte proliferation | 0.0033 | 0.0723 | 0.0111 |
| GO BP | GO:0032944 | regulation of mononuclear cell proliferation | 0.0034 | 0.0723 | 0.0112 |
| GO BP | GO:0070663 | regulation of leukocyte proliferation | 0.0039 | 0.0723 | 0.0117 |
| GO BP | GO:0009306 | protein secretion | 0.0042 | 0.1084 | 0.0276 |
| GO BP | GO:1904951 | positive regulation of establishment of protein localization | 0.0063 | 0.1084 | 0.0299 |
| GO BP | GO:0046651 | lymphocyte proliferation | 0.0094 | 0.0723 | 0.0148 |
| GO BP | GO:0032943 | mononuclear cell proliferation | 0.0097 | 0.0723 | 0.0149 |
| GO BP | GO:0050796 | regulation of insulin secretion | 0.0098 | 0.0602 | 0.0101 |
| GO BP | GO:0070661 | leukocyte proliferation | 0.012 | 0.0723 | 0.0158 |
| GO BP | GO:0010817 | regulation of hormone levels | 0.012 | 0.0964 | 0.0276 |
| GO BP | GO:0006979 | response to oxidative stress | 0.014 | 0.0843 | 0.0226 |
| GO BP | GO:0090276 | regulation of peptide hormone secretion | 0.015 | 0.0602 | 0.0116 |
| GO BP | GO:0030073 | insulin secretion | 0.015 | 0.0602 | 0.0118 |
| GO BP | GO:0044057 | regulation of system process | 0.016 | 0.0964 | 0.0295 |
| GO BP | GO:0002791 | regulation of peptide secretion | 0.016 | 0.0602 | 0.0119 |
| GO BP | GO:0090087 | regulation of peptide transport | 0.016 | 0.0602 | 0.0121 |
| GO BP | GO:0050671 | positive regulation of lymphocyte proliferation | 0.017 | 0.0482 | 0.0074 |
| GO BP | GO:0032946 | positive regulation of mononuclear cell proliferation | 0.017 | 0.0482 | 0.0075 |
| GO BP | GO:0050853 | B cell receptor signaling pathway | 0.018 | 0.0361 | 0.0038 |
| GO BP | GO:0070665 | positive regulation of leukocyte proliferation | 0.019 | 0.0482 | 0.0079 |
| GO BP | GO:0048167 | regulation of synaptic plasticity | 0.021 | 0.0482 | 0.0081 |
| DO | DOID:104 | bacterial infectious disease | 0.022 | 0.1047 | 0.0338 |
| GO BP | GO:0060292 | long term synaptic depression | 0.024 | 0.0241 | 0.0014 |
| GO BP | GO:0030072 | peptide hormone secretion | 0.026 | 0.0602 | 0.0140 |
| GO BP | GO:0042113 | B cell activation | 0.027 | 0.0602 | 0.0142 |
| DO | DOID:0050338 | primary bacterial infectious disease | 0.027 | 0.0930 | 0.0297 |
| GO BP | GO:0002790 | peptide secretion | 0.028 | 0.0602 | 0.0145 |
| GO BP | GO:0046883 | regulation of hormone secretion | 0.030 | 0.0602 | 0.0148 |
| GO BP | GO:1901654 | response to ketone | 0.032 | 0.0482 | 0.0097 |
| GO BP | GO:0015833 | peptide transport | 0.033 | 0.0602 | 0.0154 |
| GO BP | GO:0006874 | cellular calcium ion homeostasis | 0.037 | 0.0723 | 0.0222 |
| GO BP | GO:0008015 | blood circulation | 0.037 | 0.0843 | 0.0290 |
| GO BP | GO:0003013 | circulatory system process | 0.038 | 0.0843 | 0.0293 |
| GO BP | GO:0055074 | calcium ion homeostasis | 0.041 | 0.0723 | 0.0230 |
| GO BP | GO:0042886 | amide transport | 0.041 | 0.0602 | 0.0166 |
| GO BP | GO:0072503 | cellular divalent inorganic cation homeostasis | 0.046 | 0.0723 | 0.0237 |
| GO BP | GO:0046879 | hormone secretion | 0.047 | 0.0602 | 0.0173 |
Term database, term ID, term description, corresponding BH adjusted p-value generated by the hypergeometric test, Gene Ratio, and Background Ratio values are reported for all the over-represented terms with which CD38 is annotated. For an in-depth description of the column names see Table 3 legend. GO, Gene Ontology; BP, Biological Process; DO, Disease Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; BH, Benjamini-Hochberg.