Table 5.
Over-represented GO and Reactome terms associated with NRIP1 in miR-140-3p-mediated regulatory network.
| Annotation database | Term ID | Term description | BH adjusted p-value | Gene Ratio | Background ratio |
|---|---|---|---|---|---|
| GO BP | GO:0043401 | steroid hormone mediated signaling pathway | 8.14E-41 | 0.398 | 0.011 |
| GO BP | GO:0071383 | cellular response to steroid hormone stimulus | 1.44E-40 | 0.422 | 0.014 |
| GO BP | GO:0030522 | intracellular receptor signaling pathway | 1.44E-40 | 0.434 | 0.016 |
| GO BP | GO:0009755 | hormone-mediated signaling pathway | 1.45E-38 | 0.398 | 0.013 |
| GO BP | GO:0048545 | response to steroid hormone | 2.94E-35 | 0.434 | 0.022 |
| GO BP | GO:0071396 | cellular response to lipid | 9.41E-34 | 0.458 | 0.029 |
| GO BP | GO:0071407 | cellular response to organic cyclic compound | 1.55E-33 | 0.458 | 0.030 |
| GO MF | GO:0008134 | transcription factor binding | 4.77E-24 | 0.373 | 0.031 |
| GO MF | GO:0003713 | transcription coactivator activity | 1.56E-14 | 0.229 | 0.018 |
| GO MF | GO:0035257 | nuclear hormone receptor binding | 3.23E-12 | 0.157 | 0.008 |
| GO BP | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 9.27E-12 | 0.157 | 0.007 |
| GO MF | GO:0051427 | hormone receptor binding | 2.09E-11 | 0.157 | 0.009 |
| GO CC | GO:0000790 | nuclear chromatin | 1.09E-10 | 0.190 | 0.017 |
| GO CC | GO:0044454 | nuclear chromosome part | 1.16E-10 | 0.226 | 0.028 |
| GO CC | GO:0000785 | chromatin | 1.61E-10 | 0.214 | 0.025 |
| GO MF | GO:0001047 | core promoter binding | 6.28E-10 | 0.145 | 0.010 |
| GO MF | GO:0035258 | steroid hormone receptor binding | 4.19E-09 | 0.108 | 0.005 |
| GO BP | GO:0048511 | rhythmic process | 6.87E-09 | 0.181 | 0.019 |
| GO BP | GO:0007623 | circadian rhythm | 3.12E-08 | 0.145 | 0.011 |
| GO BP | GO:0032355 | response to estradiol | 5.13E-08 | 0.120 | 0.007 |
| GO MF | GO:0042826 | histone deacetylase binding | 5.96E-08 | 0.108 | 0.006 |
| GO MF | GO:0001046 | core promoter sequence-specific DNA binding | 7.31E-07 | 0.096 | 0.006 |
| GO MF | GO:0042974 | retinoic acid receptor binding | 1.63E-06 | 0.060 | 0.001 |
| GO MF | GO:0003714 | transcription corepressor activity | 2.20E-06 | 0.120 | 0.013 |
| GO MF | GO:0046965 | retinoid X receptor binding | 8.63E-06 | 0.048 | 0.001 |
| GO BP | GO:0032922 | circadian regulation of gene expression | 2.31E-05 | 0.072 | 0.003 |
| GO BP | GO:0030521 | androgen receptor signaling pathway | 3.24E-05 | 0.072 | 0.004 |
| GO BP | GO:0048608 | reproductive structure development | 0.00015 | 0.133 | 0.024 |
| GO MF | GO:0035259 | glucocorticoid receptor binding | 0.00016 | 0.036 | 0.001 |
| GO BP | GO:0061458 | reproductive system development | 0.00016 | 0.133 | 0.025 |
| GO CC | GO:0000118 | histone deacetylase complex | 0.00019 | 0.060 | 0.003 |
| GO MF | GO:0030331 | estrogen receptor binding | 0.00024 | 0.048 | 0.002 |
| GO MF | GO:0050681 | androgen receptor binding | 0.00033 | 0.048 | 0.002 |
| GO BP | GO:0019915 | lipid storage | 0.00035 | 0.060 | 0.004 |
| GO BP | GO:0051235 | maintenance of location | 0.00035 | 0.108 | 0.018 |
| GO BP | GO:0007548 | sex differentiation | 0.00084 | 0.096 | 0.016 |
| Reactome | 400253 | Circadian Clock | 0.00091 | 0.069 | 0.005 |
| GO BP | GO:0008406 | gonad development | 0.0012 | 0.084 | 0.012 |
| GO BP | GO:0045137 | development of primary sexual characteristics | 0.0013 | 0.084 | 0.013 |
| Reactome | 1368082 | RORA activates gene expression | 0.0018 | 0.042 | 0.001 |
| DO | DOID:3308 | embryonal carcinoma | 0.0028 | 0.047 | 0.003 |
| GO BP | GO:0071392 | cellular response to estradiol stimulus | 0.0040 | 0.036 | 0.002 |
| GO BP | GO:0010876 | lipid localization | 0.011 | 0.084 | 0.021 |
| DO | DOID:11612 | polycystic ovary syndrome | 0.020 | 0.081 | 0.021 |
| DO | DOID:688 | embryonal cancer | 0.020 | 0.128 | 0.047 |
| DO | DOID:2994 | germ cell cancer | 0.029 | 0.128 | 0.051 |
| GO BP | GO:0022602 | ovulation cycle process | 0.030 | 0.036 | 0.005 |
| GO BP | GO:0008585 | female gonad development | 0.037 | 0.036 | 0.005 |
| GO BP | GO:0046545 | development of primary female sexual characteristics | 0.040 | 0.036 | 0.006 |
| GO BP | GO:0042698 | ovulation cycle | 0.048 | 0.036 | 0.006 |
Term database, term ID, term description, corresponding BH adjusted p-value generated by the hypergeometric test, Gene Ratio, and Background Ratio values are reported for all the over-represented terms with which NRIP1 is annotated. For an in-depth description of the column names see Table 3 legend. GO, Gene Ontology; BP, Biological Process; MF, Molecular Function; CC, Cellular Component; DO, Disease Ontology; BH, Benjamini-Hochberg.