Table 2.

Main Functions of Mammalian-Specific Genes

Enriched Function	Representative Terms	N Genes	Corrected P Value
1. Immune response	1.1 immune response (GO)	14	2.2E-3
	1.2 cytokine activity (GO)	13	1.6E-10
	1.3 Jak-STAT signaling pathway (KEGG)	6	5.5E-4
2. Reproduction	2.1 reproductive process in a multicellular organism (GO)	12	1.3E-3
	2.2 spermatogenesis (GO)	10	9.2E-4
3. Secreted protein	3.1 extracellular region (GO)	64	1.8E-15
	3.2 secreted (Uniprot)	59	2.8E-14
	3.3 signal peptide (Uniprot)	60	7.0E-10

Note.—The results shown are for human genes classified as “mam-basal” (class 2).