Table 3.
Results of Focused Rereview of Surgical Lung Biopsies in Patients With Idiopathic Interstitial Pneumonia
| Characteristics | Initial Review Before IPAF Criteria, No. (%), n = 36 | Focused Rereview for Features of IPAF Criteria, No. (%), n = 36 | P valuea |
|---|---|---|---|
| Classified as IPAF | 26 (72.2) | 33 (91.7) | .02 |
| Met histopathologic IPAF criteria | 16 (44.4) | 26 (72.0) | .002 |
| NSIP | 4 (11.1) | 12 (33.3) | .008 |
| OP | 3 (8.3) | 4 (11.1) | >.99 |
| NSIP/OP overlap | 0 (0.0) | 1 (2.8) | >.99 |
| ILA and GCs | 3 (8.3) | 8 (22.2) | .06 |
| Diffuse LPI | 6 (16.7) | 12 (33.3) | .03 |
| Multicompartment involvementb | |||
| Intrinsic airway disease | 1 (2.8) | 1 (2.8) | >.99 |
| Pulmonary vasculopathy | 20 (55.6) | 20 (55.6) | >.99 |
| Pleural or pericardial thickening or effusion | 2 (5.6) | 4 (11.1) | .50 |
| UIP pattern | 32 (88.9) | 32 (88.9) | >.99 |
| Mixed UIP-NSIP pattern | 3 (9.4) | 11 (34.4) | .009 |
Abbreviations: GC, germinal center; ILA, interstitial lymphoid aggregates; IPAF, interstitial pneumonia with autoimmune features; LPI, lymphoplasmacytic infiltrates; NSIP, nonspecific interstitial pneumonia; OP, organizing pneumonia; UIP, usual interstitial pneumonia.
a
Bolded font denotes significant P-values at a .05 level of significance.
b
No patient had unexplained pleural or pericardial effusion or thickening.